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PUBLICATIONS

  • "Human CSTF2 RNA recognition motif domain binds to a U-Rich RNA sequence through a multistep binding process." Masoumzadeh E and Latham MP. Biochemistry 2024 Sep 21. doi: 10.1021/acs.biochem.4c00408.

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  • "How a highly acidic SH3 domain folds in the absence of its charged peptide target." Jaramillo-Martinez V, Dominguez MJ, Bell GM, Souness ME, Carhart AH, Cuibus MA, Masoumzadeh E, Lantz BJ, Adkins AJ, Latham MP, Ball KA, Stollar EJ. Protein Sci. 2023 May; 32(5):e4635. doi: 10.1002/pro.4635.

 

  • "Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1." Azatian SB, Canny MD, Latham MP.  J Biomol NMR. 2022 Dec 21. doi: 10.1007/s10858-022-00409-w.

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  • "Structural features of Dnase1L3 responsible for serum antigen clearance." McCord JJ, Engavale M, Masoumzadeh E, Villarreal J, Mapp B, Latham MP, Keyel PA, Sutton RB. Commun Biol. 2022 Aug 16;5(1):825. doi: 10.1038/s42003-022-03755-5.

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  • "LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex." Canny MD and Latham MP.  eLife 2022;11:e69579 doi: 10.7554/eLife.69579.

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  • "Electrostatic interactions between CSTF2 and pre-mRNA drive cleavage and polyadenylation." Masoumzadeh E, Grozdanov PN, Jetly A, MacDonald CC, Latham MP. (2022) Biophys J. Jan 25;S0006-3495(22)00005-4. doi: 10.1016/j.bpj.2022.01.005.

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  • "Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C." Rahman S, Beikzadeh M, Latham MP. (2021) Sci Rep. Mar 29;11(1):7089. doi: 10.1038/s41598-021-86552-0.

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  • "The dynamic nature of the Mre11-Rad50 DNA break repair complex." Beikzadeh M, Latham MP. Prog Biophys Mol Biol. 2021 Aug;163:14-22. doi: 10.1016/j.pbiomolbio.2020.10.007.

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  • "A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3′ end processing is associated with intellectual disability in humans." Grozdanov PN*, Masoumzadeh E*, Kalscheuer VM, Bienvenu T, Billuart P, Delrue MA, Latham MP**, MacDonald CC**. (2020) Nucleic Acids Res. Sep 25;48(17):9804-9821. doi: 10.1093/nar/gkaa689. *Co-first author. **Co-corresponding author.

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  • "A survey of reported disease-related mutations in the MRE11-RAD50-NBS1 complex." Rahman S, Canny MD, Buschmann TA, Latham MP (2020). Cells. Jul 13;9(7):1678. doi: 10.3390/cells9071678.

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  • "Maturation of the functional mouse CRES amyloid from globular form." Hewetson A, Khan NH, Dominguez MJ, Do HQ, Kusko RE, Borcik CG, Rigden DJ, Keegan RM, Sutton RB, Latham MP, Wylie BJ, Cornwall GA (2020) PNAS. Jul 14;117(28):16363-16372.

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  • "Mutation of conserved Mre11 residues alter protein dynamics to separate nuclease functions." Rahman S*, Beikzadeh M*, Canny MD, Kaur N, Latham MP (2020) J Mol Biol. May 1;432(10):3289-3308. *Co-first author.

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  • "Adjacent mutations in the ABC ATPase D-loop of archaeal Rad50 disrupt the allosteric regulation of ATP hydrolysis through different mechanisms." Boswell ZK, Canny MD, Buschmann TA, Sang J, Latham MP (2020) Nucleic Acids Res. 48(5):2457-2472.

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  • "The functional mammalian CRES (Cystatin-Related Epididymal Spermatogenic) amyloid is antiparallel β-Sheet rich and forms a metastable oligomer during assembly." Do HQ, Hewetson A, Myers C, Khan NH, Hastert MC, M Harsini F, Latham MP, Wylie BJ, Sutton RB, Cornwall GA (2019) Sci Rep. 9 (1), 9210.

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  • "A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases." Khan NH, Bui AA, Xiao Y, Sutton RB, Shaw RW, Wylie BJ, Latham MP (2019) PLoS One. 14 (4), e0214440.

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  • "Increasing the buffering capacity of minimal media leads to higher protein yield." Azatian SB, Kaur N, Latham MP (2019) J Biomol NMR. 73 (1-2), 11-17.

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  • "Methyl-based NMR spectroscopy methods for uncovering structural dynamics in large proteins and protein complexes." Boswell ZK and Latham MP (2019) Biochemistry. 58(3):144-155.

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  • "The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity." Grozdanov PN, Masoumzadeh E, Latham MP, MacDonald CC (2018) Nucleic Acids Res. 46(22):12022-12039.

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  • "A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair." Boswell ZK, Rahman S, Canny MD, Latham MP (2018) Sci Rep. 8(1):1639.

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  • "Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency." Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. (2018) Nat Biotechnol. 36(1):95-102.

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  • "A similar in vitro and in cell lysate folding intermediate for the FF domain." Latham MP and Kay LE (2014) J Mol Biol. 426(19):3214-20.

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  • "Viscosity-dependent kinetics of protein conformational exchange: microviscosity effects and the need for a small viscogen." Sekhar A, Latham MP, Vallurupalli P, Kay LE (2014) J Phys Chem B. 118(17):4546-51.

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  • "Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling." Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. (2014) PLOS Genetics. 10(3).

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  • "Understanding the mechanism of proteasome 20S core particle gating." Latham MP, Sekhar A, Kay LE (2014) Proc Natl Acad Sci USA. 111(15): 5532-7.

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  • "Phosphorylation releases constraints to domain motion in ERK2." Xiao Y, Lee T, Latham MP, Warner LR, Tanimoto A, Pardi A, Ahn NG (2014) Proc Natl Acad Sci USA. 111(7): 256-11.

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  • "53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark." Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D. (2013) Nature. 499:50-4.

 

  • "Probing non-specific interactions of Ca²⁺ -calmodulin in E. coli lysate." Latham MP, Kay LE (2013) J Biomol NMR. 55(3): 239-47.

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  • "Is buffer a good proxy for a crowded cell-like environment? A comparative NMR study of calmodulin side-chain dynamics in buffer and E. coli lysate." Latham MP, Kay LE (2012) PLoS One. 7(10): e48226.

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  • "NMR chemical exchange as a probe for ligand-binding kinetics in a theophylline-binding RNA aptamer." Latham MP, Zimmermann GR, Pardi A (2009) J Am Chem Soc. 131(14): 5052-3.

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  • "Comparison of alignment tensors generated for native tRNAval using magnetic fields and liquid crystalline media." Latham MP, Hanson P, Brown DJ, Pardi A (2008) J Biomol NMR. 40(2): 83-94.

 

  • "NMR methods for studying the structure and dynamics of RNA." Latham MP, Brown DJ, McCallum SA, Pardi A (2005) Chembiochem. 6(9): 1492-505.

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